Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome
المؤلفون المشاركون
Nestler, John E.
Cheang, Kai I.
Sistrun, Sakita N.
Morel, Kelley S.
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS).
Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown.
We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS.
Methods.
Obese PCOS ( n = 16 ) and normal ( n = 15 ) women underwent 8 weeks of a hypocaloric diet.
The Matsuda index, area under the curve DCI-IPG ( AUC DCI-IPG ), AUC insulin , and AUC DCI-IPG / AUC insulin were measured during a 2 hr OGTT at baseline and 8 weeks.
Results.
PCOS women had lower AUC DCI-IPG / AUC insulin at baseline and a significant relationship between AUC DCI-IPG / AUC insulin and Matsuda index ( p = 0.0003 ), which was not present in controls.
Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, p = 0.6281 ).
Weight loss in PCOS women did not change the relationship between AUC DCI-IPG / AUC insulin and Matsuda index ( p = 0.0100 ), and this relationship remained absent in control women.
Conclusion.
The association between AUC DCI-IPG / AUC insulin and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss.
DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheang, Kai I.& Sistrun, Sakita N.& Morel, Kelley S.& Nestler, John E.. 2016. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheang, Kai I.…[et al.]. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheang, Kai I.& Sistrun, Sakita N.& Morel, Kelley S.& Nestler, John E.. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر