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Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome
Joint Authors
Nestler, John E.
Cheang, Kai I.
Sistrun, Sakita N.
Morel, Kelley S.
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS).
Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown.
We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS.
Methods.
Obese PCOS ( n = 16 ) and normal ( n = 15 ) women underwent 8 weeks of a hypocaloric diet.
The Matsuda index, area under the curve DCI-IPG ( AUC DCI-IPG ), AUC insulin , and AUC DCI-IPG / AUC insulin were measured during a 2 hr OGTT at baseline and 8 weeks.
Results.
PCOS women had lower AUC DCI-IPG / AUC insulin at baseline and a significant relationship between AUC DCI-IPG / AUC insulin and Matsuda index ( p = 0.0003 ), which was not present in controls.
Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, p = 0.6281 ).
Weight loss in PCOS women did not change the relationship between AUC DCI-IPG / AUC insulin and Matsuda index ( p = 0.0100 ), and this relationship remained absent in control women.
Conclusion.
The association between AUC DCI-IPG / AUC insulin and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss.
DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity.
American Psychological Association (APA)
Cheang, Kai I.& Sistrun, Sakita N.& Morel, Kelley S.& Nestler, John E.. 2016. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
Modern Language Association (MLA)
Cheang, Kai I.…[et al.]. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
American Medical Association (AMA)
Cheang, Kai I.& Sistrun, Sakita N.& Morel, Kelley S.& Nestler, John E.. Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105979