The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes

الملخص EN

Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes.

Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance.

Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance.

There is a lack of evidence of inositol use in T2DM.

We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM.

This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7.0–10.0%) already treated with glucose-lowering agents.

Patients (23.1% males, mean age of 60.8 ± 11.7 years) took for three months a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg) orally twice a day as add-on supplement to their glucose-lowering drugs.

Possible occurrence of side effects was investigated.

After three months of treatment fasting blood glucose ( 192.6 ± 60.2 versus 160.9 ± 36.4 ; p = 0.02 ) and HbA1c levels ( 8.6 ± 0.9 versus 7.7 ± 0.9 ; p = 0.02 ) significantly decreased compared to baseline.

There was no significant difference in blood pressure, lipid profile, and BMI levels.

None of the participants reported side effects.

In conclusion, a supplementation with a combination of myo- and d-chiro-inositol is an effective and safe strategy for improving glycemic control in T2DM.