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The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes
Joint Authors
Pintaudi, Basilio
Di Vieste, Giacoma
Bonomo, Matteo
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes.
Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance.
Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance.
There is a lack of evidence of inositol use in T2DM.
We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM.
This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7.0–10.0%) already treated with glucose-lowering agents.
Patients (23.1% males, mean age of 60.8 ± 11.7 years) took for three months a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg) orally twice a day as add-on supplement to their glucose-lowering drugs.
Possible occurrence of side effects was investigated.
After three months of treatment fasting blood glucose ( 192.6 ± 60.2 versus 160.9 ± 36.4 ; p = 0.02 ) and HbA1c levels ( 8.6 ± 0.9 versus 7.7 ± 0.9 ; p = 0.02 ) significantly decreased compared to baseline.
There was no significant difference in blood pressure, lipid profile, and BMI levels.
None of the participants reported side effects.
In conclusion, a supplementation with a combination of myo- and d-chiro-inositol is an effective and safe strategy for improving glycemic control in T2DM.
American Psychological Association (APA)
Pintaudi, Basilio& Di Vieste, Giacoma& Bonomo, Matteo. 2016. The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106044
Modern Language Association (MLA)
Pintaudi, Basilio…[et al.]. The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. International Journal of Endocrinology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106044
American Medical Association (AMA)
Pintaudi, Basilio& Di Vieste, Giacoma& Bonomo, Matteo. The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106044