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Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy
المؤلفون المشاركون
Khan, Abidullah
Ayub, Maimoona
Khan, Wazir Mohammad
المصدر
International Journal of Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Hyperammonemia resulting from chronic liver disease (CLD) can potentially challenge and damage any organ system of the body, particularly the brain.
However, there is still some controversy regarding the diagnostic or prognostic values of serum ammonia in patients with over hepatic encephalopathy, especially in the setting of acute-on-chronic or chronic liver failure.
Moreover, the association of serum ammonia with worsening Child-Pugh grade of liver cirrhosis has not been studied.
Objective.
This study was conducted to solve the controversy regarding the association between hyperammonemia and cirrhosis, especially hepatic encephalopathy in chronically failed liver.
Material and Methods.
In this study, 171 cirrhotic patients had their serum ammonia measured and analyzed by SPSS version 16.
Chi-squared test and one-way ANOVA were applied.
Results.
The study had 110 male and 61 female participants.
The mean age of all the participants in years was 42.33±7.60.
The mean duration (years) of CLD was 10.15±3.53 while the mean Child-Pugh (CP) score was 8.84±3.30.
Chronic viral hepatitis alone was responsible for 71.3% of the cases.
Moreover, 86.5% of participants had hepatic encephalopathy (HE).
The frequency of hyperammonemia was 67.3%, more frequent in males (N=81, z-score = 2.4, and P<0.05) than in females (N=34, z-score = 2.4, and P<0.05), and had a statistically significant relationship with increasing CP grade of cirrhosis (χ2(2) = 27.46, P<0.001, Phi = 0.40, and P<0.001).
Furthermore, serum ammonia level was higher in patients with hepatic encephalopathy than in those without it; P<0.001.
Conclusion.
Hyperammonemia is associated with both increasing Child-Pugh grade of liver cirrhosis and hepatic encephalopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Abidullah& Ayub, Maimoona& Khan, Wazir Mohammad. 2016. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Abidullah…[et al.]. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Abidullah& Ayub, Maimoona& Khan, Wazir Mohammad. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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