Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy
Joint Authors
Khan, Abidullah
Ayub, Maimoona
Khan, Wazir Mohammad
Source
International Journal of Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Hyperammonemia resulting from chronic liver disease (CLD) can potentially challenge and damage any organ system of the body, particularly the brain.
However, there is still some controversy regarding the diagnostic or prognostic values of serum ammonia in patients with over hepatic encephalopathy, especially in the setting of acute-on-chronic or chronic liver failure.
Moreover, the association of serum ammonia with worsening Child-Pugh grade of liver cirrhosis has not been studied.
Objective.
This study was conducted to solve the controversy regarding the association between hyperammonemia and cirrhosis, especially hepatic encephalopathy in chronically failed liver.
Material and Methods.
In this study, 171 cirrhotic patients had their serum ammonia measured and analyzed by SPSS version 16.
Chi-squared test and one-way ANOVA were applied.
Results.
The study had 110 male and 61 female participants.
The mean age of all the participants in years was 42.33±7.60.
The mean duration (years) of CLD was 10.15±3.53 while the mean Child-Pugh (CP) score was 8.84±3.30.
Chronic viral hepatitis alone was responsible for 71.3% of the cases.
Moreover, 86.5% of participants had hepatic encephalopathy (HE).
The frequency of hyperammonemia was 67.3%, more frequent in males (N=81, z-score = 2.4, and P<0.05) than in females (N=34, z-score = 2.4, and P<0.05), and had a statistically significant relationship with increasing CP grade of cirrhosis (χ2(2) = 27.46, P<0.001, Phi = 0.40, and P<0.001).
Furthermore, serum ammonia level was higher in patients with hepatic encephalopathy than in those without it; P<0.001.
Conclusion.
Hyperammonemia is associated with both increasing Child-Pugh grade of liver cirrhosis and hepatic encephalopathy.
American Psychological Association (APA)
Khan, Abidullah& Ayub, Maimoona& Khan, Wazir Mohammad. 2016. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
Modern Language Association (MLA)
Khan, Abidullah…[et al.]. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
American Medical Association (AMA)
Khan, Abidullah& Ayub, Maimoona& Khan, Wazir Mohammad. Hyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy. International Journal of Hepatology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106221