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Activity of Medicinal Plant Extracts on Multiplication of Mycobacterium tuberculosis under Reduced Oxygen Conditions Using Intracellular and Axenic Assays
المؤلفون المشاركون
Gupta, Pooja D.
Bhatter, P.
Mistry, N.
المصدر
International Journal of Microbiology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
Test the activity of selected medicinal plant extracts on multiplication of Mycobacterium tuberculosis under reduced oxygen concentration which represents nonreplicating conditions.
Material and Methods.
Acetone, ethanol and aqueous extracts of the plants Acorus calamus L.
(rhizome), Ocimum sanctum L.
(leaf), Piper nigrum L.
(seed), and Pueraria tuberosa DC.
(tuber) were tested on Mycobacterium tuberculosis H37Rv intracellularly using an epithelial cell (A549) infection model.
The extracts found to be active intracellularly were further studied axenically under reducing oxygen concentrations.
Results and Conclusions.
Intracellular multiplication was inhibited ≥60% by five of the twelve extracts.
Amongst these 5 extracts, in axenic culture, P.
nigrum (acetone) was active under aerobic, microaerophilic, and anaerobic conditions indicating presence of multiple components acting at different levels and P.
tuberosa (aqueous) showed bactericidal activity under microaerophilic and anaerobic conditions implying the influence of anaerobiosis on its efficacy.
P.
nigrum (aqueous) and A.
calamus (aqueous and ethanol) extracts were not active under axenic conditions but only inhibited intracellular growth of Mycobacterium tuberculosis, suggesting activation of host defense mechanisms to mediate bacterial killing rather than direct bactericidal activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhatter, P.& Gupta, Pooja D.& Mistry, N.. 2016. Activity of Medicinal Plant Extracts on Multiplication of Mycobacterium tuberculosis under Reduced Oxygen Conditions Using Intracellular and Axenic Assays. International Journal of Microbiology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhatter, P.…[et al.]. Activity of Medicinal Plant Extracts on Multiplication of Mycobacterium tuberculosis under Reduced Oxygen Conditions Using Intracellular and Axenic Assays. International Journal of Microbiology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhatter, P.& Gupta, Pooja D.& Mistry, N.. Activity of Medicinal Plant Extracts on Multiplication of Mycobacterium tuberculosis under Reduced Oxygen Conditions Using Intracellular and Axenic Assays. International Journal of Microbiology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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