Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review
المؤلفون المشاركون
Krishnappa, Vinod
Gupta, Mohit
Manu, Gurusidda
Kwatra, Shivani
Owusu, Osei-Tutu
Raina, Rupesh
المصدر
International Journal of Nephrology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for lymphoproliferative disorders and bone marrow failure states including aplastic anemia and thalassemia.
However, its use has been limited by the increased treatment related complications, including acute kidney injury (AKI) with an incidence ranging from 20% to 73%.
AKI after HSCT has been associated with an increased risk of mortality.
The incidence of AKI reported in recipients of myeloablative allogeneic transplant is considerably higher in comparison to other subclasses mainly due to use of cyclosporine and development of graft-versus-host disease (GVHD) in allogeneic groups.
Acute GVHD is by itself a major independent risk factor for the development of AKI in HSCT recipients.
The other major risk factors are sepsis, nephrotoxic medications (amphotericin B, acyclovir, aminoglycosides, and cyclosporine), hepatic sinusoidal obstruction syndrome (SOS), thrombotic microangiopathy (TMA), marrow infusion toxicity, and tumor lysis syndrome.
The mainstay of management of AKI in these patients is avoidance of risk factors contributing to AKI, including use of reduced intensity-conditioning regimen, close monitoring of nephrotoxic medications, and use of alternative antifungals for prophylaxis against infection.
Also, early identification and effective management of sepsis, tumor lysis syndrome, marrow infusion toxicity, and hepatic SOS help in reducing the incidence of AKI in HSCT recipients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krishnappa, Vinod& Gupta, Mohit& Manu, Gurusidda& Kwatra, Shivani& Owusu, Osei-Tutu& Raina, Rupesh. 2016. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krishnappa, Vinod…[et al.]. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krishnappa, Vinod& Gupta, Mohit& Manu, Gurusidda& Kwatra, Shivani& Owusu, Osei-Tutu& Raina, Rupesh. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106350
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر