Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review
Joint Authors
Krishnappa, Vinod
Gupta, Mohit
Manu, Gurusidda
Kwatra, Shivani
Owusu, Osei-Tutu
Raina, Rupesh
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for lymphoproliferative disorders and bone marrow failure states including aplastic anemia and thalassemia.
However, its use has been limited by the increased treatment related complications, including acute kidney injury (AKI) with an incidence ranging from 20% to 73%.
AKI after HSCT has been associated with an increased risk of mortality.
The incidence of AKI reported in recipients of myeloablative allogeneic transplant is considerably higher in comparison to other subclasses mainly due to use of cyclosporine and development of graft-versus-host disease (GVHD) in allogeneic groups.
Acute GVHD is by itself a major independent risk factor for the development of AKI in HSCT recipients.
The other major risk factors are sepsis, nephrotoxic medications (amphotericin B, acyclovir, aminoglycosides, and cyclosporine), hepatic sinusoidal obstruction syndrome (SOS), thrombotic microangiopathy (TMA), marrow infusion toxicity, and tumor lysis syndrome.
The mainstay of management of AKI in these patients is avoidance of risk factors contributing to AKI, including use of reduced intensity-conditioning regimen, close monitoring of nephrotoxic medications, and use of alternative antifungals for prophylaxis against infection.
Also, early identification and effective management of sepsis, tumor lysis syndrome, marrow infusion toxicity, and hepatic SOS help in reducing the incidence of AKI in HSCT recipients.
American Psychological Association (APA)
Krishnappa, Vinod& Gupta, Mohit& Manu, Gurusidda& Kwatra, Shivani& Owusu, Osei-Tutu& Raina, Rupesh. 2016. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
Modern Language Association (MLA)
Krishnappa, Vinod…[et al.]. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
American Medical Association (AMA)
Krishnappa, Vinod& Gupta, Mohit& Manu, Gurusidda& Kwatra, Shivani& Owusu, Osei-Tutu& Raina, Rupesh. Acute Kidney Injury in Hematopoietic Stem Cell Transplantation: A Review. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106350