Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness

المؤلفون المشاركون

Xia, Tian
Hao, Weiju
Shang, Yazhuo
Xu, Shouhong
Liu, Honglai

المصدر

International Journal of Polymer Science

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-05-04

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الفيزياء

الملخص EN

Diblock copolymers (mPEG-b-PDPA), which were designed to possess pH-sensitivity as well as amphipathy, were used as an intelligent lock in the liposomal membrane.

The so-called pH-sensitive liposomes were prepared by simple mixing of the synthesized mPEG-b-PDPA with phospholipids and cholesterol.

Fluorescence polarization at pH 7.4 showed that the membrane stability of the hybrid liposome was significantly increased compared with the pure liposome.

Therefore, in the neutral environment, the leakage of doxorubicin (DOX) was inhibited.

However, when pH decreased to 6.0, DOX release rate increased by 60% due to the escape of copolymer.

The effects of the membrane composition and the PDPA segment length on bilayer membrane functions were investigated.

These results revealed that the synthesized copolymers increased the difference in DOX cumulative release between pH 7.4 and 6.0, that is, improved the pH-controllability of the drug release from hybrid liposomes.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xia, Tian& Hao, Weiju& Shang, Yazhuo& Xu, Shouhong& Liu, Honglai. 2016. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106816

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xia, Tian…[et al.]. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106816

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xia, Tian& Hao, Weiju& Shang, Yazhuo& Xu, Shouhong& Liu, Honglai. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106816

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1106816