Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness
Joint Authors
Xia, Tian
Hao, Weiju
Shang, Yazhuo
Xu, Shouhong
Liu, Honglai
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diblock copolymers (mPEG-b-PDPA), which were designed to possess pH-sensitivity as well as amphipathy, were used as an intelligent lock in the liposomal membrane.
The so-called pH-sensitive liposomes were prepared by simple mixing of the synthesized mPEG-b-PDPA with phospholipids and cholesterol.
Fluorescence polarization at pH 7.4 showed that the membrane stability of the hybrid liposome was significantly increased compared with the pure liposome.
Therefore, in the neutral environment, the leakage of doxorubicin (DOX) was inhibited.
However, when pH decreased to 6.0, DOX release rate increased by 60% due to the escape of copolymer.
The effects of the membrane composition and the PDPA segment length on bilayer membrane functions were investigated.
These results revealed that the synthesized copolymers increased the difference in DOX cumulative release between pH 7.4 and 6.0, that is, improved the pH-controllability of the drug release from hybrid liposomes.
American Psychological Association (APA)
Xia, Tian& Hao, Weiju& Shang, Yazhuo& Xu, Shouhong& Liu, Honglai. 2016. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106816
Modern Language Association (MLA)
Xia, Tian…[et al.]. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106816
American Medical Association (AMA)
Xia, Tian& Hao, Weiju& Shang, Yazhuo& Xu, Shouhong& Liu, Honglai. Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106816