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Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application
المؤلفون المشاركون
Hiep, Nguyen Thi
Khon, Huynh Chan
Hai, Nguyen Dai
Hoang Phuc, Dang
Ngoc Phuc Chau, Do
Thi Thu Hoai, Nguyen
Chi Bao, Bui
Toi, Vo Van
المصدر
International Journal of Polymer Science
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A new hydrogel made of hyaluronan, poly(vinylphosphonic acid), and chitosan (HA/PVPA/CS hydrogel) was fabricated and characterized to be used for skin wound healing application.
Firstly, the component ratio of hydrogel was studied to optimize the reaction effectiveness.
Next, its microstructure was observed by light microscope.
The chemical interaction in hydrogel was evaluated by nuclear magnetic resonance spectroscopy and Fourier transform-infrared spectroscopy.
Then, a study on its degradation rate was performed.
After that, antibacterial activity of the hydrogel was examined by agar diffusion method.
Finally, in vivo study was performed to evaluate hydrogel’s biocompatibility.
The results showed that the optimized hydrogel had a three-dimensional highly porous structure with the pore size ranging from about 25 µm to less than 125 µm.
Besides, with a degradation time of two weeks, it could give enough time for the formation of extracellular matrix framework during remodeling stages.
Furthermore, the antibacterial test showed that hydrogel has antimicrobial activity against E.
coli.
Finally, in vivo study indicated that the hydrogel was not rejected by the immune system and could enhance wound healing process.
Overall, HA/PVPA/CS hydrogel was successfully fabricated and results implied its potential for wound healing applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoang Phuc, Dang& Hiep, Nguyen Thi& Ngoc Phuc Chau, Do& Thi Thu Hoai, Nguyen& Khon, Huynh Chan& Toi, Vo Van…[et al.]. 2016. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoang Phuc, Dang…[et al.]. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoang Phuc, Dang& Hiep, Nguyen Thi& Ngoc Phuc Chau, Do& Thi Thu Hoai, Nguyen& Khon, Huynh Chan& Toi, Vo Van…[et al.]. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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