Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application
Joint Authors
Hiep, Nguyen Thi
Khon, Huynh Chan
Hai, Nguyen Dai
Hoang Phuc, Dang
Ngoc Phuc Chau, Do
Thi Thu Hoai, Nguyen
Chi Bao, Bui
Toi, Vo Van
Source
International Journal of Polymer Science
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A new hydrogel made of hyaluronan, poly(vinylphosphonic acid), and chitosan (HA/PVPA/CS hydrogel) was fabricated and characterized to be used for skin wound healing application.
Firstly, the component ratio of hydrogel was studied to optimize the reaction effectiveness.
Next, its microstructure was observed by light microscope.
The chemical interaction in hydrogel was evaluated by nuclear magnetic resonance spectroscopy and Fourier transform-infrared spectroscopy.
Then, a study on its degradation rate was performed.
After that, antibacterial activity of the hydrogel was examined by agar diffusion method.
Finally, in vivo study was performed to evaluate hydrogel’s biocompatibility.
The results showed that the optimized hydrogel had a three-dimensional highly porous structure with the pore size ranging from about 25 µm to less than 125 µm.
Besides, with a degradation time of two weeks, it could give enough time for the formation of extracellular matrix framework during remodeling stages.
Furthermore, the antibacterial test showed that hydrogel has antimicrobial activity against E.
coli.
Finally, in vivo study indicated that the hydrogel was not rejected by the immune system and could enhance wound healing process.
Overall, HA/PVPA/CS hydrogel was successfully fabricated and results implied its potential for wound healing applications.
American Psychological Association (APA)
Hoang Phuc, Dang& Hiep, Nguyen Thi& Ngoc Phuc Chau, Do& Thi Thu Hoai, Nguyen& Khon, Huynh Chan& Toi, Vo Van…[et al.]. 2016. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
Modern Language Association (MLA)
Hoang Phuc, Dang…[et al.]. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
American Medical Association (AMA)
Hoang Phuc, Dang& Hiep, Nguyen Thi& Ngoc Phuc Chau, Do& Thi Thu Hoai, Nguyen& Khon, Huynh Chan& Toi, Vo Van…[et al.]. Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1106829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106829