Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
المؤلفون المشاركون
Kals, Jaak
Tootsi, Kaspar
Paapstel, Kaido
Märtson, Aare
Zilmer, Mihkel
المصدر
International Journal of Rheumatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality.
Evidence is lacking about whether arterial stiffness is involved in OA.
The objective of our study was to find out associations between OA, arterial stiffness, and adipokines.
Design.
Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness.
Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method.
Correlation between variables was determined using Spearman’s rho.
Multiple regression analysis with a stepwise selection procedure was employed.
Results.
Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) ( r = 0.272 , p = 0.023 ).
We found that OA grade was also associated with leptin and MMP-3 levels ( r h o = - 0.246 , p = 0.040 and r h o = 0.235 , p = 0.050 , resp.).
In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index ( r h o = 0.293 , p = 0.006 and r h o = - 0.249 , p = 0.003 , resp.).
Conclusions.
Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines.
Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tootsi, Kaspar& Kals, Jaak& Zilmer, Mihkel& Paapstel, Kaido& Märtson, Aare. 2016. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tootsi, Kaspar…[et al.]. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tootsi, Kaspar& Kals, Jaak& Zilmer, Mihkel& Paapstel, Kaido& Märtson, Aare. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر