Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
Joint Authors
Kals, Jaak
Tootsi, Kaspar
Paapstel, Kaido
Märtson, Aare
Zilmer, Mihkel
Source
International Journal of Rheumatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality.
Evidence is lacking about whether arterial stiffness is involved in OA.
The objective of our study was to find out associations between OA, arterial stiffness, and adipokines.
Design.
Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness.
Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method.
Correlation between variables was determined using Spearman’s rho.
Multiple regression analysis with a stepwise selection procedure was employed.
Results.
Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) ( r = 0.272 , p = 0.023 ).
We found that OA grade was also associated with leptin and MMP-3 levels ( r h o = - 0.246 , p = 0.040 and r h o = 0.235 , p = 0.050 , resp.).
In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index ( r h o = 0.293 , p = 0.006 and r h o = - 0.249 , p = 0.003 , resp.).
Conclusions.
Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines.
Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA.
American Psychological Association (APA)
Tootsi, Kaspar& Kals, Jaak& Zilmer, Mihkel& Paapstel, Kaido& Märtson, Aare. 2016. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
Modern Language Association (MLA)
Tootsi, Kaspar…[et al.]. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
American Medical Association (AMA)
Tootsi, Kaspar& Kals, Jaak& Zilmer, Mihkel& Paapstel, Kaido& Märtson, Aare. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness. International Journal of Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106909