Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation
المؤلفون المشاركون
Tanaka, Makoto
Yamada, Hiroyuki
Nishikawa, Satoshi
Mori, Hiroshi
Ochi, Yasuo
Horai, Naoto
Li, Minqi
Amizuka, Norio
المصدر
International Journal of Rheumatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The role of cathepsin K in joint degradation in a model of collagen-induced arthritis (CIA) in cynomolgus monkey was examined using biochemical markers and histology.
Joint swelling, urinary C-telopeptide of type II collagen (CTX-II), deoxypyridinoline (DPD), and N- and C-telopeptides of type I collagen (NTX and CTX-I, resp.) were analyzed.
Immunohistochemistry of type II collagen, cathepsin K, and CTX-II were performed using joints.
Joint swelling reached peak on day 42 and continued at this level.
The CTX-II level peaked on day 28 and declined thereafter, while CTX-I, NTX, and DPD reached plateau on day 43.
Joint swelling was positively correlated with CTX-II increases on days 20 and 42/43, with increases in CTX-I and NTX/Cr on days 42/43 and 84, and with DPD increases throughout the study period.
Intense cathepsin K staining was observed in osteoclasts and in articular cartilage and synovial tissue in arthritic joints.
CTX-II was present in the superficial layer of articular cartilage in CIA monkeys.
Evidence from biochemical markers suggests that matrix degradation in the CIA model starts with degradation of cartilage, rather than bone resorption.
Cathepsin K expressed in osteoclasts, articular cartilage, and synovial tissue may contribute to degradation of cartilage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tanaka, Makoto& Yamada, Hiroyuki& Nishikawa, Satoshi& Mori, Hiroshi& Ochi, Yasuo& Horai, Naoto…[et al.]. 2016. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tanaka, Makoto…[et al.]. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tanaka, Makoto& Yamada, Hiroyuki& Nishikawa, Satoshi& Mori, Hiroshi& Ochi, Yasuo& Horai, Naoto…[et al.]. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر