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Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation
Joint Authors
Tanaka, Makoto
Yamada, Hiroyuki
Nishikawa, Satoshi
Mori, Hiroshi
Ochi, Yasuo
Horai, Naoto
Li, Minqi
Amizuka, Norio
Source
International Journal of Rheumatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The role of cathepsin K in joint degradation in a model of collagen-induced arthritis (CIA) in cynomolgus monkey was examined using biochemical markers and histology.
Joint swelling, urinary C-telopeptide of type II collagen (CTX-II), deoxypyridinoline (DPD), and N- and C-telopeptides of type I collagen (NTX and CTX-I, resp.) were analyzed.
Immunohistochemistry of type II collagen, cathepsin K, and CTX-II were performed using joints.
Joint swelling reached peak on day 42 and continued at this level.
The CTX-II level peaked on day 28 and declined thereafter, while CTX-I, NTX, and DPD reached plateau on day 43.
Joint swelling was positively correlated with CTX-II increases on days 20 and 42/43, with increases in CTX-I and NTX/Cr on days 42/43 and 84, and with DPD increases throughout the study period.
Intense cathepsin K staining was observed in osteoclasts and in articular cartilage and synovial tissue in arthritic joints.
CTX-II was present in the superficial layer of articular cartilage in CIA monkeys.
Evidence from biochemical markers suggests that matrix degradation in the CIA model starts with degradation of cartilage, rather than bone resorption.
Cathepsin K expressed in osteoclasts, articular cartilage, and synovial tissue may contribute to degradation of cartilage.
American Psychological Association (APA)
Tanaka, Makoto& Yamada, Hiroyuki& Nishikawa, Satoshi& Mori, Hiroshi& Ochi, Yasuo& Horai, Naoto…[et al.]. 2016. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
Modern Language Association (MLA)
Tanaka, Makoto…[et al.]. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
American Medical Association (AMA)
Tanaka, Makoto& Yamada, Hiroyuki& Nishikawa, Satoshi& Mori, Hiroshi& Ochi, Yasuo& Horai, Naoto…[et al.]. Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. International Journal of Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106915