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Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms
المؤلفون المشاركون
Olga, Freylihman
Malashicheva, Anna
Kostina, Daria
Kostina, Aleksandra
Irtyuga, Olga
Voronkina, Irina
Smagina, Larisa
Ignatieva, Elena
Gavriliuk, Natalia
Uspensky, Vladimir
Moiseeva, Olga
Vaage, Jarle
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Thoracic aortic aneurysm develops as a result of complex series of events that alter the cellular structure and the composition of the extracellular matrix of the aortic wall.
The purpose of the present work was to study the cellular functions of endothelial and smooth muscle cells from the patients with aneurysms of the thoracic aorta.
We studied endothelial and smooth muscle cells from aneurysms in patients with bicuspid aortic valve and with tricuspid aortic valve.
The expression of key markers of endothelial (CD31, vWF, and VE-cadherin) and smooth muscle (SMA, SM22α, calponin, and vimentin) cells as well extracellular matrix and MMP activity was studied as well as and apoptosis and cell proliferation.
Expression of functional markers of endothelial and smooth muscle cells was reduced in patient cells.
Cellular proliferation, migration, and synthesis of extracellular matrix proteins are attenuated in the cells of the patients.
We show for the first time that aortic endothelial cell phenotype is changed in the thoracic aortic aneurysms compared to normal aortic wall.
In conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Malashicheva, Anna& Kostina, Daria& Kostina, Aleksandra& Irtyuga, Olga& Voronkina, Irina& Smagina, Larisa…[et al.]. 2016. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Malashicheva, Anna…[et al.]. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Malashicheva, Anna& Kostina, Daria& Kostina, Aleksandra& Irtyuga, Olga& Voronkina, Irina& Smagina, Larisa…[et al.]. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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