Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms
Joint Authors
Olga, Freylihman
Malashicheva, Anna
Kostina, Daria
Kostina, Aleksandra
Irtyuga, Olga
Voronkina, Irina
Smagina, Larisa
Ignatieva, Elena
Gavriliuk, Natalia
Uspensky, Vladimir
Moiseeva, Olga
Vaage, Jarle
Source
International Journal of Vascular Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Thoracic aortic aneurysm develops as a result of complex series of events that alter the cellular structure and the composition of the extracellular matrix of the aortic wall.
The purpose of the present work was to study the cellular functions of endothelial and smooth muscle cells from the patients with aneurysms of the thoracic aorta.
We studied endothelial and smooth muscle cells from aneurysms in patients with bicuspid aortic valve and with tricuspid aortic valve.
The expression of key markers of endothelial (CD31, vWF, and VE-cadherin) and smooth muscle (SMA, SM22α, calponin, and vimentin) cells as well extracellular matrix and MMP activity was studied as well as and apoptosis and cell proliferation.
Expression of functional markers of endothelial and smooth muscle cells was reduced in patient cells.
Cellular proliferation, migration, and synthesis of extracellular matrix proteins are attenuated in the cells of the patients.
We show for the first time that aortic endothelial cell phenotype is changed in the thoracic aortic aneurysms compared to normal aortic wall.
In conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis.
American Psychological Association (APA)
Malashicheva, Anna& Kostina, Daria& Kostina, Aleksandra& Irtyuga, Olga& Voronkina, Irina& Smagina, Larisa…[et al.]. 2016. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
Modern Language Association (MLA)
Malashicheva, Anna…[et al.]. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
American Medical Association (AMA)
Malashicheva, Anna& Kostina, Daria& Kostina, Aleksandra& Irtyuga, Olga& Voronkina, Irina& Smagina, Larisa…[et al.]. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International Journal of Vascular Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1107106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107106