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The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases
المؤلفون المشاركون
Kipanyula, Maulilio John
Kimaro, Wahabu Hamisi
Etet, Paul F. Seke
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-15
دولة النشر
مصر
عدد الصفحات
20
الملخص EN
The ongoing epidemics of metabolic diseases and increase in the older population have increased the incidences of neurodegenerative diseases.
Evidence from murine and cell line models has implicated calcineurin-nuclear factor of activated T-lymphocytes (NFAT) signaling pathway, a Ca2+/calmodulin-dependent major proinflammatory pathway, in the pathogenesis of these diseases.
Neurotoxins such as amyloid-β, tau protein, and α-synuclein trigger abnormal calcineurin/NFAT signaling activities.
Additionally increased activities of endogenous regulators of calcineurin like plasma membrane Ca2+-ATPase (PMCA) and regulator of calcineurin 1 (RCAN1) also cause neuronal and glial loss and related functional alterations, in neurodegenerative diseases, psychotic disorders, epilepsy, and traumatic brain and spinal cord injuries.
Treatment with calcineurin/NFAT inhibitors induces some degree of neuroprotection and decreased reactive gliosis in the central and peripheral nervous system.
In this paper, we summarize and discuss the current understanding of the roles of calcineurin/NFAT signaling in physiology and pathologies of the adult and developing nervous system, with an emphasis on recent reports and cutting-edge findings.
Calcineurin/NFAT signaling is known for its critical roles in the developing and adult nervous system.
Its role in physiological and pathological processes is still controversial.
However, available data suggest that its beneficial and detrimental effects are context-dependent.
In view of recent reports calcineurin/NFAT signaling is likely to serve as a potential therapeutic target for neurodegenerative diseases and conditions.
This review further highlights the need to characterize better all factors determining the outcome of calcineurin/NFAT signaling in diseases and the downstream targets mediating the beneficial and detrimental effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kipanyula, Maulilio John& Kimaro, Wahabu Hamisi& Etet, Paul F. Seke. 2016. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kipanyula, Maulilio John…[et al.]. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kipanyula, Maulilio John& Kimaro, Wahabu Hamisi& Etet, Paul F. Seke. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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