The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases
Joint Authors
Kipanyula, Maulilio John
Kimaro, Wahabu Hamisi
Etet, Paul F. Seke
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-15
Country of Publication
Egypt
No. of Pages
20
Abstract EN
The ongoing epidemics of metabolic diseases and increase in the older population have increased the incidences of neurodegenerative diseases.
Evidence from murine and cell line models has implicated calcineurin-nuclear factor of activated T-lymphocytes (NFAT) signaling pathway, a Ca2+/calmodulin-dependent major proinflammatory pathway, in the pathogenesis of these diseases.
Neurotoxins such as amyloid-β, tau protein, and α-synuclein trigger abnormal calcineurin/NFAT signaling activities.
Additionally increased activities of endogenous regulators of calcineurin like plasma membrane Ca2+-ATPase (PMCA) and regulator of calcineurin 1 (RCAN1) also cause neuronal and glial loss and related functional alterations, in neurodegenerative diseases, psychotic disorders, epilepsy, and traumatic brain and spinal cord injuries.
Treatment with calcineurin/NFAT inhibitors induces some degree of neuroprotection and decreased reactive gliosis in the central and peripheral nervous system.
In this paper, we summarize and discuss the current understanding of the roles of calcineurin/NFAT signaling in physiology and pathologies of the adult and developing nervous system, with an emphasis on recent reports and cutting-edge findings.
Calcineurin/NFAT signaling is known for its critical roles in the developing and adult nervous system.
Its role in physiological and pathological processes is still controversial.
However, available data suggest that its beneficial and detrimental effects are context-dependent.
In view of recent reports calcineurin/NFAT signaling is likely to serve as a potential therapeutic target for neurodegenerative diseases and conditions.
This review further highlights the need to characterize better all factors determining the outcome of calcineurin/NFAT signaling in diseases and the downstream targets mediating the beneficial and detrimental effects.
American Psychological Association (APA)
Kipanyula, Maulilio John& Kimaro, Wahabu Hamisi& Etet, Paul F. Seke. 2016. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
Modern Language Association (MLA)
Kipanyula, Maulilio John…[et al.]. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
American Medical Association (AMA)
Kipanyula, Maulilio John& Kimaro, Wahabu Hamisi& Etet, Paul F. Seke. The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases. Journal of Aging Research. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1107425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107425