Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents
المؤلفون المشاركون
Kaplancıklı, Zafer Asım
Altıntop, Mehlika Dilek
Sever, Belgin
Cantürk, Zerrin
Özdemir, Ahmet
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes.
The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method.
Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv.
Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis (ATCC 29212) than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E.
faecalis.
Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus.
On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5.
These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata.
According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaplancıklı, Zafer Asım& Altıntop, Mehlika Dilek& Sever, Belgin& Cantürk, Zerrin& Özdemir, Ahmet. 2016. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaplancıklı, Zafer Asım…[et al.]. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaplancıklı, Zafer Asım& Altıntop, Mehlika Dilek& Sever, Belgin& Cantürk, Zerrin& Özdemir, Ahmet. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر