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Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents
Joint Authors
Kaplancıklı, Zafer Asım
Altıntop, Mehlika Dilek
Sever, Belgin
Cantürk, Zerrin
Özdemir, Ahmet
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes.
The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method.
Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv.
Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis (ATCC 29212) than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E.
faecalis.
Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus.
On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5.
These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata.
According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity.
American Psychological Association (APA)
Kaplancıklı, Zafer Asım& Altıntop, Mehlika Dilek& Sever, Belgin& Cantürk, Zerrin& Özdemir, Ahmet. 2016. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
Modern Language Association (MLA)
Kaplancıklı, Zafer Asım…[et al.]. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
American Medical Association (AMA)
Kaplancıklı, Zafer Asım& Altıntop, Mehlika Dilek& Sever, Belgin& Cantürk, Zerrin& Özdemir, Ahmet. Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107548