Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity
المؤلفون المشاركون
Mendonça Junior, F. J. B.
Barbosa-Filho, José M.
Lorenzo, Vitor Prates
Scotti, Luciana
Scotti, Marcus Tullius
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cancer is a major public health problem with limited success of available treatments, pointing to the need for new strategies to be developed.
Phosphoethanolamine exhibits broad antitumor activity in a variety of tumor cells and potent inhibitor effects on tumor progress in vivo.
Once-used organophosphates inhibit acetylcholinesterase (AChE), resulting in toxic effects to the user.
As this group is present in phosphoethanolamine, we perform prediction of the in silico metabolism of phosphoethanolamine and submit this series to a docking study on AChE.
A total of 10 metabolites were indicated by the prediction, including ammonia and hydroxylamine, which were not included in the study.
Using a group of 8 organophosphorus whose pIC50 values ranged from 5.92 to 9.47 as template, we observed that no compound present in the phosphoethanolamine series had a binding energy lower than that of organophosphorus, suggesting that the series has low inhibitory power on AChE.
In light of this, we conclude that phosphoethanolamine and its predicted metabolites do not significantly inhibit AChE to cause a cholinergic crisis.
This finding highlights the importance of investigating this compound as lead for potential anticancer agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lorenzo, Vitor Prates& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.& Scotti, Luciana& Scotti, Marcus Tullius. 2016. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lorenzo, Vitor Prates…[et al.]. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lorenzo, Vitor Prates& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.& Scotti, Luciana& Scotti, Marcus Tullius. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر