Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity
Joint Authors
Mendonça Junior, F. J. B.
Barbosa-Filho, José M.
Lorenzo, Vitor Prates
Scotti, Luciana
Scotti, Marcus Tullius
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cancer is a major public health problem with limited success of available treatments, pointing to the need for new strategies to be developed.
Phosphoethanolamine exhibits broad antitumor activity in a variety of tumor cells and potent inhibitor effects on tumor progress in vivo.
Once-used organophosphates inhibit acetylcholinesterase (AChE), resulting in toxic effects to the user.
As this group is present in phosphoethanolamine, we perform prediction of the in silico metabolism of phosphoethanolamine and submit this series to a docking study on AChE.
A total of 10 metabolites were indicated by the prediction, including ammonia and hydroxylamine, which were not included in the study.
Using a group of 8 organophosphorus whose pIC50 values ranged from 5.92 to 9.47 as template, we observed that no compound present in the phosphoethanolamine series had a binding energy lower than that of organophosphorus, suggesting that the series has low inhibitory power on AChE.
In light of this, we conclude that phosphoethanolamine and its predicted metabolites do not significantly inhibit AChE to cause a cholinergic crisis.
This finding highlights the importance of investigating this compound as lead for potential anticancer agents.
American Psychological Association (APA)
Lorenzo, Vitor Prates& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.& Scotti, Luciana& Scotti, Marcus Tullius. 2016. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
Modern Language Association (MLA)
Lorenzo, Vitor Prates…[et al.]. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
American Medical Association (AMA)
Lorenzo, Vitor Prates& Mendonça Junior, F. J. B.& Barbosa-Filho, José M.& Scotti, Luciana& Scotti, Marcus Tullius. Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity. Journal of Chemistry. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107651