Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women
المؤلفون المشاركون
Guclu, Metin
Topyildiz, Figen
Kiyici, Sinem
Gul, Zulfiye
Sigirli, Deniz
Kisakol, Gurcan
Cavun, Sinan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus.
Methods.
Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled.
A mixed meal test was applied to the patients while continuing with their daily medications.
Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels.
The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated.
Results.
Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline ( 294.4 ± 57.5 versus 234.5 ± 59.4 pg/mL) ( p < 0.00 1 ).
Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared ( p = 0.001 ).
Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment ( p = 0.035 ).
Conclusion.
These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Topyildiz, Figen& Kiyici, Sinem& Gul, Zulfiye& Sigirli, Deniz& Guclu, Metin& Kisakol, Gurcan…[et al.]. 2016. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Topyildiz, Figen…[et al.]. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Topyildiz, Figen& Kiyici, Sinem& Gul, Zulfiye& Sigirli, Deniz& Guclu, Metin& Kisakol, Gurcan…[et al.]. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107954
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر