Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women
Joint Authors
Guclu, Metin
Topyildiz, Figen
Kiyici, Sinem
Gul, Zulfiye
Sigirli, Deniz
Kisakol, Gurcan
Cavun, Sinan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To investigate the effect of exenatide treatment on serum ghrelin levels in obese female patients with type 2 diabetes mellitus.
Methods.
Fourteen female patients with type 2 diabetes mellitus being treated with metformin and exenatide were enrolled.
A mixed meal test was applied to the patients while continuing with their daily medications.
Blood samples were taken before and at 60, 120, and 180 minutes following mixed meal test to measure serum total ghrelin, glucose, and insulin levels.
The following week, exenatide treatment of the patients was paused for 24 hours and the same experimental procedures were repeated.
Results.
Serum ghrelin levels were suppressed significantly at 180 minutes with exenatide treatment compared with baseline ( 294.4 ± 57.5 versus 234.5 ± 59.4 pg/mL) ( p < 0.00 1 ).
Serum ghrelin levels at 180 minutes were statistically different when percentage change in serum ghrelin levels after mixed meal tests with and without exenatide usage were compared ( p = 0.001 ).
Estimated total area under the curve values for serum ghrelin concentrations was also significantly lower with exenatide compared with omitted treatment ( p = 0.035 ).
Conclusion.
These results suggest that the effect of exenatide on weight loss may be related with the suppression of serum ghrelin levels, which is an orexigenic peptide.
American Psychological Association (APA)
Topyildiz, Figen& Kiyici, Sinem& Gul, Zulfiye& Sigirli, Deniz& Guclu, Metin& Kisakol, Gurcan…[et al.]. 2016. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
Modern Language Association (MLA)
Topyildiz, Figen…[et al.]. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
American Medical Association (AMA)
Topyildiz, Figen& Kiyici, Sinem& Gul, Zulfiye& Sigirli, Deniz& Guclu, Metin& Kisakol, Gurcan…[et al.]. Exenatide Treatment Causes Suppression of Serum Ghrelin Levels following Mixed Meal Test in Obese Diabetic Women. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107954