Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Tong, Xiaolin
Sha, Hong
Zhao, Dong
Zhao, Jingbo
Gregersen, Hans
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats.
Here we investigated the mechanisms of such effects of CRT.
Diabetes was induced by a single injection of 40 mg/kg of STZ.
CRT was poured into the stomach by gastric lavage once daily for 60 days.
The remodeling parameters were obtained from diabetic (DM), CRT treated diabetic (T1, 50 g/kg; T2, 25 g/kg), and normal (Con) rats.
Expressions of advanced glycation end product (AGE), AGE receptor, transforming growth factor-β1 (TGF-β1), and TGF-β1 receptor in the colon wall were immunochemically detected and quantitatively analyzed.
The association between the expressions of those proteins and the remodeling parameters was analyzed.
The expressions of those proteins were significantly higher in different colon layers in the DM group (P<0.05, P<0.01) and highly correlated to the remodeling parameters.
Furthermore, the expressions of those proteins were significantly decreased in the T1 group (P<0.05, P<0.01) but not in the T2 group (P>0.05).
The corrective effect on the expressions of those proteins is likely to be one molecular pathway for the improvement of CRT on the diabetes-induced colon remodeling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sha, Hong& Zhao, Dong& Tong, Xiaolin& Gregersen, Hans& Zhao, Jingbo. 2015. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sha, Hong…[et al.]. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sha, Hong& Zhao, Dong& Tong, Xiaolin& Gregersen, Hans& Zhao, Jingbo. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر