Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
Joint Authors
Tong, Xiaolin
Sha, Hong
Zhao, Dong
Zhao, Jingbo
Gregersen, Hans
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats.
Here we investigated the mechanisms of such effects of CRT.
Diabetes was induced by a single injection of 40 mg/kg of STZ.
CRT was poured into the stomach by gastric lavage once daily for 60 days.
The remodeling parameters were obtained from diabetic (DM), CRT treated diabetic (T1, 50 g/kg; T2, 25 g/kg), and normal (Con) rats.
Expressions of advanced glycation end product (AGE), AGE receptor, transforming growth factor-β1 (TGF-β1), and TGF-β1 receptor in the colon wall were immunochemically detected and quantitatively analyzed.
The association between the expressions of those proteins and the remodeling parameters was analyzed.
The expressions of those proteins were significantly higher in different colon layers in the DM group (P<0.05, P<0.01) and highly correlated to the remodeling parameters.
Furthermore, the expressions of those proteins were significantly decreased in the T1 group (P<0.05, P<0.01) but not in the T2 group (P>0.05).
The corrective effect on the expressions of those proteins is likely to be one molecular pathway for the improvement of CRT on the diabetes-induced colon remodeling.
American Psychological Association (APA)
Sha, Hong& Zhao, Dong& Tong, Xiaolin& Gregersen, Hans& Zhao, Jingbo. 2015. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
Modern Language Association (MLA)
Sha, Hong…[et al.]. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
American Medical Association (AMA)
Sha, Hong& Zhao, Dong& Tong, Xiaolin& Gregersen, Hans& Zhao, Jingbo. Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107986