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Immune Cells and Inflammation in Diabetic Nephropathy
المؤلفون المشاركون
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) is a serious complication of diabetes.
At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys.
Such inflammation can then drive the classical markers of fibrosis and structural remodeling.
As a result, resolution of immune-mediated inflammation is critical towards achieving a cure for DN.
Many immune cells play a part in DN, including key members of both the innate and adaptive immune systems.
While these cells were classically understood to primarily function against pathogen insult, it has also become increasingly clear that they also serve a major role as internal sensors of damage.
In fact, damage sensing may serve as the impetus for much of the inflammation that occurs in DN, in a vicious positive feedback cycle.
Although direct targeting of these proinflammatory cells may be difficult, new approaches that focus on their metabolic profiles may be able to alleviate DN significantly, especially since dysregulation of the local metabolic environment may well be responsible for triggering inflammation to begin with.
In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Zihan& Zheng, Feng. 2015. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Zihan& Zheng, Feng. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Zihan& Zheng, Feng. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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