![](/images/graphics-bg.png)
Immune Cells and Inflammation in Diabetic Nephropathy
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a serious complication of diabetes.
At its core, DN is a metabolic disorder which can also manifest itself in terms of local inflammation in the kidneys.
Such inflammation can then drive the classical markers of fibrosis and structural remodeling.
As a result, resolution of immune-mediated inflammation is critical towards achieving a cure for DN.
Many immune cells play a part in DN, including key members of both the innate and adaptive immune systems.
While these cells were classically understood to primarily function against pathogen insult, it has also become increasingly clear that they also serve a major role as internal sensors of damage.
In fact, damage sensing may serve as the impetus for much of the inflammation that occurs in DN, in a vicious positive feedback cycle.
Although direct targeting of these proinflammatory cells may be difficult, new approaches that focus on their metabolic profiles may be able to alleviate DN significantly, especially since dysregulation of the local metabolic environment may well be responsible for triggering inflammation to begin with.
In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles.
American Psychological Association (APA)
Zheng, Zihan& Zheng, Feng. 2015. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
Modern Language Association (MLA)
Zheng, Zihan& Zheng, Feng. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
American Medical Association (AMA)
Zheng, Zihan& Zheng, Feng. Immune Cells and Inflammation in Diabetic Nephropathy. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1107988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107988