Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
المؤلفون المشاركون
Andersen, Jesper L.
Søgaard, Ditte
Østergård, Torben
Baranowski, Marcin
Vigelsø, Andreas Hansen
Dela, Flemming
Helge, Jørn Wulff
Błachnio-Zabielska, Agnieszka
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man.
We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle.
Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age: 33.1 ± 1.4 yrs; BMI: 26.4 ± 0.4 kg/m2) and sixteen matched Controls (age: 31.3 ± 1.5 yrs; BMI: 25.3 ± 0.7 kg/m2) performed 10 weeks of endurance training three times a week at 70% of VO2max on a bicycle ergometer.
Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained.
Insulin sensitivity was significantly lower in Offsprings compared to control subjects ( p < 0.01 ) but improved in both groups after 10 weeks of endurance training (Off: 17 ± 6 %; Con: 12 ± 9 %, p < 0.01 ).
The content of muscle ceramide, DAG, and their subspecies were similar between groups and did not change in response to the endurance training except for an overall reduction in C22:0-Cer ( p < 0.05 ).
Finally, the intervention induced an increase in AKT protein expression (Off: 27 ± 11 %; Con: 20 ± 24 %, p < 0.05 ).
This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Søgaard, Ditte& Østergård, Torben& Błachnio-Zabielska, Agnieszka& Baranowski, Marcin& Vigelsø, Andreas Hansen& Andersen, Jesper L.…[et al.]. 2016. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Søgaard, Ditte…[et al.]. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Søgaard, Ditte& Østergård, Torben& Błachnio-Zabielska, Agnieszka& Baranowski, Marcin& Vigelsø, Andreas Hansen& Andersen, Jesper L.…[et al.]. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108012
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر