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Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity
Joint Authors
Andersen, Jesper L.
Søgaard, Ditte
Østergård, Torben
Baranowski, Marcin
Vigelsø, Andreas Hansen
Dela, Flemming
Helge, Jørn Wulff
Błachnio-Zabielska, Agnieszka
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent in man.
We evaluated if an increase in insulin sensitivity after endurance training was accompanied by changes in these lipids in skeletal muscle.
Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age: 33.1 ± 1.4 yrs; BMI: 26.4 ± 0.4 kg/m2) and sixteen matched Controls (age: 31.3 ± 1.5 yrs; BMI: 25.3 ± 0.7 kg/m2) performed 10 weeks of endurance training three times a week at 70% of VO2max on a bicycle ergometer.
Before and after the intervention a hyperinsulinemic-euglycemic clamp and VO2max test were performed and muscle biopsies obtained.
Insulin sensitivity was significantly lower in Offsprings compared to control subjects ( p < 0.01 ) but improved in both groups after 10 weeks of endurance training (Off: 17 ± 6 %; Con: 12 ± 9 %, p < 0.01 ).
The content of muscle ceramide, DAG, and their subspecies were similar between groups and did not change in response to the endurance training except for an overall reduction in C22:0-Cer ( p < 0.05 ).
Finally, the intervention induced an increase in AKT protein expression (Off: 27 ± 11 %; Con: 20 ± 24 %, p < 0.05 ).
This study showed no relation between insulin sensitivity and ceramide or DAG content suggesting that ceramide and DAG are not major players in the early phase of insulin resistance in human muscle.
American Psychological Association (APA)
Søgaard, Ditte& Østergård, Torben& Błachnio-Zabielska, Agnieszka& Baranowski, Marcin& Vigelsø, Andreas Hansen& Andersen, Jesper L.…[et al.]. 2016. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
Modern Language Association (MLA)
Søgaard, Ditte…[et al.]. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
American Medical Association (AMA)
Søgaard, Ditte& Østergård, Torben& Błachnio-Zabielska, Agnieszka& Baranowski, Marcin& Vigelsø, Andreas Hansen& Andersen, Jesper L.…[et al.]. Training Does Not Alter Muscle Ceramide and Diacylglycerol in Offsprings of Type 2 Diabetic Patients Despite Improved Insulin Sensitivity. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108012