Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats
المؤلفون المشاركون
Han, Li-ping
Li, Chun-jun
Sun, Bei
Xie, Yun
Guan, Yue
Ma, Ze-jun
Chen, Li-ming
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury.
Celastrol is a potent immunosuppressive and anti-inflammatory agent.
So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal models.
The present study was aimed at investigating protective effects of celastrol on the liver injury in diabetic rats and at elucidating the possible involved mechanisms.
We analyzed the liver histopathological and biochemical changes and the expressions of TLR4 mediated signaling pathway.
Compared to the normal control group, diabetic rats were found to have obvious steatohepatitis and proinflammatory cytokine activities were significantly upregulated.
Celastrol-treated diabetic rats show reduced hepatic inflammation and macrophages infiltration.
The expressions of TLR4, MyD88, NF-κB, and downstream inflammatory factors IL-1β and TNFα in the hepatic tissue of treated rats were downregulated in a dose-dependent manner.
We firstly found that celastrol treatment could delay the progression of diabetic liver disease in type 2 diabetic rats via inhibition of TLR4/MyD88/NF-κB signaling cascade pathways and its downstream inflammatory effectors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Li-ping& Li, Chun-jun& Sun, Bei& Xie, Yun& Guan, Yue& Ma, Ze-jun…[et al.]. 2016. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Li-ping…[et al.]. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Li-ping& Li, Chun-jun& Sun, Bei& Xie, Yun& Guan, Yue& Ma, Ze-jun…[et al.]. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر