Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats
Joint Authors
Han, Li-ping
Li, Chun-jun
Sun, Bei
Xie, Yun
Guan, Yue
Ma, Ze-jun
Chen, Li-ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immune and inflammatory pathways play a central role in the pathogenesis of diabetic liver injury.
Celastrol is a potent immunosuppressive and anti-inflammatory agent.
So far, there is no evidence regarding the mechanism of innate immune alterations of celastrol on diabetic liver injury in type 2 diabetic animal models.
The present study was aimed at investigating protective effects of celastrol on the liver injury in diabetic rats and at elucidating the possible involved mechanisms.
We analyzed the liver histopathological and biochemical changes and the expressions of TLR4 mediated signaling pathway.
Compared to the normal control group, diabetic rats were found to have obvious steatohepatitis and proinflammatory cytokine activities were significantly upregulated.
Celastrol-treated diabetic rats show reduced hepatic inflammation and macrophages infiltration.
The expressions of TLR4, MyD88, NF-κB, and downstream inflammatory factors IL-1β and TNFα in the hepatic tissue of treated rats were downregulated in a dose-dependent manner.
We firstly found that celastrol treatment could delay the progression of diabetic liver disease in type 2 diabetic rats via inhibition of TLR4/MyD88/NF-κB signaling cascade pathways and its downstream inflammatory effectors.
American Psychological Association (APA)
Han, Li-ping& Li, Chun-jun& Sun, Bei& Xie, Yun& Guan, Yue& Ma, Ze-jun…[et al.]. 2016. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
Modern Language Association (MLA)
Han, Li-ping…[et al.]. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
American Medical Association (AMA)
Han, Li-ping& Li, Chun-jun& Sun, Bei& Xie, Yun& Guan, Yue& Ma, Ze-jun…[et al.]. Protective Effects of Celastrol on Diabetic Liver Injury via TLR4MyD88NF-κB Signaling Pathway in Type 2 Diabetic Rats. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108025