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Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study
المؤلفون المشاركون
Satirapoj, Bancha
Supasyndh, Ouppatham
Aramsaowapak, Kasemsan
Tangwonglert, Theerasak
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Tubulointerstitial injury is both a key feature of diabetic nephropathy and an important predictor of renal dysfunction.
Novel tubular biomarkers related to renal injury in diabetic nephropathy could improve risk stratification and prediction.
Methods.
A total of 303 type 2 diabetic patients were followed up.
The baseline urine values of cystatin-C to creatinine ratio (UCCR), angiotensinogen to creatinine ratio (UANG), NGAL to creatinine ratio (UNGAL), and KIM-1 to creatinine ratio (UKIM-1) were measured.
The primary outcome was a decline in estimated GFR of ≥25% yearly from baseline.
Results.
Urine tubular biomarkers of UCCR, UANG, UNGAL, and UKIM-1 were significantly higher according to the degree of albuminuria and all were significantly higher among patients with rapid decline in estimated GFR of ≥25% yearly from baseline.
All biomarkers predicted primary outcomes with ROC for UCCR of 0.72; 95% CI 0.64–0.79, for UANG of 0.71; 95% CI 0.63–0.79, for UNGAL of 0.64; 95% CI 0.56–0.72, and for UKIM-1 of 0.71; 95% CI 0.63–0.79.
Using multivariate Cox regression analysis, the number of patients with rapid renal progression was higher among those in the upper quartiles of all biomarkers than in those in the lower quartiles.
Conclusions.
Type 2 diabetic patients with high levels of urine tubular biomarkers had a more rapid decline in renal function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Satirapoj, Bancha& Aramsaowapak, Kasemsan& Tangwonglert, Theerasak& Supasyndh, Ouppatham. 2016. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Satirapoj, Bancha…[et al.]. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Satirapoj, Bancha& Aramsaowapak, Kasemsan& Tangwonglert, Theerasak& Supasyndh, Ouppatham. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108049
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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