Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study
Joint Authors
Satirapoj, Bancha
Supasyndh, Ouppatham
Aramsaowapak, Kasemsan
Tangwonglert, Theerasak
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Tubulointerstitial injury is both a key feature of diabetic nephropathy and an important predictor of renal dysfunction.
Novel tubular biomarkers related to renal injury in diabetic nephropathy could improve risk stratification and prediction.
Methods.
A total of 303 type 2 diabetic patients were followed up.
The baseline urine values of cystatin-C to creatinine ratio (UCCR), angiotensinogen to creatinine ratio (UANG), NGAL to creatinine ratio (UNGAL), and KIM-1 to creatinine ratio (UKIM-1) were measured.
The primary outcome was a decline in estimated GFR of ≥25% yearly from baseline.
Results.
Urine tubular biomarkers of UCCR, UANG, UNGAL, and UKIM-1 were significantly higher according to the degree of albuminuria and all were significantly higher among patients with rapid decline in estimated GFR of ≥25% yearly from baseline.
All biomarkers predicted primary outcomes with ROC for UCCR of 0.72; 95% CI 0.64–0.79, for UANG of 0.71; 95% CI 0.63–0.79, for UNGAL of 0.64; 95% CI 0.56–0.72, and for UKIM-1 of 0.71; 95% CI 0.63–0.79.
Using multivariate Cox regression analysis, the number of patients with rapid renal progression was higher among those in the upper quartiles of all biomarkers than in those in the lower quartiles.
Conclusions.
Type 2 diabetic patients with high levels of urine tubular biomarkers had a more rapid decline in renal function.
American Psychological Association (APA)
Satirapoj, Bancha& Aramsaowapak, Kasemsan& Tangwonglert, Theerasak& Supasyndh, Ouppatham. 2016. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
Modern Language Association (MLA)
Satirapoj, Bancha…[et al.]. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
American Medical Association (AMA)
Satirapoj, Bancha& Aramsaowapak, Kasemsan& Tangwonglert, Theerasak& Supasyndh, Ouppatham. Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108049