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Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Zhang, Xiao-xi
Zhao, Hai-lu
Pan, Yan-Hong
Qiao, Yong-chao
Shen, Jian
He, Lan
Hong, Xue-zhi
Tian, Fang
Liang, Ling
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-29
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was to investigate the changes of regulatory T cells (Treg), interleukin-6 (IL-6), IL-10, transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM).
Methods.
We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-β, and TNF-α in T2DM patients versus healthy controls.
Results.
A total of 91 articles (5642 cases and 7378 controls) were included for this meta-analysis.
Compared with the controls (all p<0.001), the patients had increased serum levels of IL-6, TGF-β, and TNF-α but decreased the percentage of peripheral CD4+CD25+Foxp3+Treg and serum IL-10 level.
Furthermore, the percentage of peripheral CD4+CD25+Foxp3+Treg (p<0.001) and serum IL-10 level (p=0.033) were significantly lower in the patients with complication and in the patients without complication, respectively.
No significant changes about the percentage of CD4+CD25+Treg (p=0.360) and serum IL-17 level (p=0.459) were found in T2DM patients.
Conclusions.
T2DM patients have decreased the percentage of peripheral CD4+CD25+Foxp3+Treg and levels of serum IL-10 but elevated serum levels of IL-6, TGF-β, and TNF-α.
Presence of diabetic complications further lowers the peripheral CD4+CD25+Foxp3+Treg number.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiao, Yong-chao& Shen, Jian& He, Lan& Hong, Xue-zhi& Tian, Fang& Pan, Yan-Hong…[et al.]. 2016. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiao, Yong-chao…[et al.]. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiao, Yong-chao& Shen, Jian& He, Lan& Hong, Xue-zhi& Tian, Fang& Pan, Yan-Hong…[et al.]. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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