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Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Joint Authors
Zhang, Xiao-xi
Zhao, Hai-lu
Pan, Yan-Hong
Qiao, Yong-chao
Shen, Jian
He, Lan
Hong, Xue-zhi
Tian, Fang
Liang, Ling
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Objective.
The aim of this study was to investigate the changes of regulatory T cells (Treg), interleukin-6 (IL-6), IL-10, transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM).
Methods.
We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-β, and TNF-α in T2DM patients versus healthy controls.
Results.
A total of 91 articles (5642 cases and 7378 controls) were included for this meta-analysis.
Compared with the controls (all p<0.001), the patients had increased serum levels of IL-6, TGF-β, and TNF-α but decreased the percentage of peripheral CD4+CD25+Foxp3+Treg and serum IL-10 level.
Furthermore, the percentage of peripheral CD4+CD25+Foxp3+Treg (p<0.001) and serum IL-10 level (p=0.033) were significantly lower in the patients with complication and in the patients without complication, respectively.
No significant changes about the percentage of CD4+CD25+Treg (p=0.360) and serum IL-17 level (p=0.459) were found in T2DM patients.
Conclusions.
T2DM patients have decreased the percentage of peripheral CD4+CD25+Foxp3+Treg and levels of serum IL-10 but elevated serum levels of IL-6, TGF-β, and TNF-α.
Presence of diabetic complications further lowers the peripheral CD4+CD25+Foxp3+Treg number.
American Psychological Association (APA)
Qiao, Yong-chao& Shen, Jian& He, Lan& Hong, Xue-zhi& Tian, Fang& Pan, Yan-Hong…[et al.]. 2016. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
Modern Language Association (MLA)
Qiao, Yong-chao…[et al.]. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
American Medical Association (AMA)
Qiao, Yong-chao& Shen, Jian& He, Lan& Hong, Xue-zhi& Tian, Fang& Pan, Yan-Hong…[et al.]. Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1108075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108075