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The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats
المؤلفون المشاركون
Gao, Qin
Yu, Ying
Jia, Xian-Jie
Zhang, Wei-ping
Fang, Ting-ting
Hu, Jie
Ma, Shan-Feng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of low dose ethanol feeding in diabetic rats and analyze its underlying mechanisms.
Methods.
Male Sprague-Dawley rats were divided into 4 groups: control (Con), diabetes at 4 weeks (DM4W), diabetes at 8 weeks (DM8W), and EtOH + DM8W.
After 8 weeks, hemodynamic parameters were recorded and heart weight/body weight (H/B) and hydroxyproline (Hp) content in myocardium were measured.
Morphology of collagen in myocardial tissue was observed with Masson’s trichrome staining method and collagen volume fraction (CVF) was analysed.
The mRNA expression of ALDH2 was assessed with Real-Time PCR.
The protein expressions of p-JNK and JNK were evaluated using western blot.
Results.
In contrast to Con group, there was no difference in hemodynamic parameters in DM4W group, but mean arterial pressure and heart rate were decreased in DM8W group, and the ratios of H/B, Hp, and CVF were markedly increased.
ALDH2 mRNA expression was decreased, while the ratio of p-JNK/JNK were increased.
Compared with DM8W group, the above indexes were improved in EtOH + DM8W group.
Conclusion.
With low dose ethanol intervention, enhanced ALDH2 expression can antagonize the happening of myocardial fibrosis in diabetic rats, which may be relevant with downregulating the JNK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Ying& Jia, Xian-Jie& Zhang, Wei-ping& Fang, Ting-ting& Hu, Jie& Ma, Shan-Feng…[et al.]. 2016. The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108082
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Ying…[et al.]. The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108082
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Ying& Jia, Xian-Jie& Zhang, Wei-ping& Fang, Ting-ting& Hu, Jie& Ma, Shan-Feng…[et al.]. The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108082
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108082
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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