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Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy
المؤلفون المشاركون
Sun, Guang-dong
Li, Xiaoxia
Li, Chaoyuan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) remains a leading cause of mortality worldwide despite advances in its prevention and management.
A comprehensive understanding of factors contributing to DN is required to develop more effective therapeutic options.
It is becoming more evident that histone acetylation (HAc), as one of the epigenetic mechanisms, is thought to be associated with the etiology of diabetic vascular complications such as diabetic retinopathy (DR), diabetic cardiomyopathy (DCM), and DN.
Histone acetylases (HATs) and histone deacetylases (HDACs) are the well-known regulators of reversible acetylation in the amino-terminal domains of histone and nonhistone proteins.
In DN, however, the roles of histone acetylation (HAc) and these enzymes are still controversial.
Some new evidence has revealed that HATs and HDACs inhibitors are renoprotective in cellular and animal models of DN, while, on the other hand, upregulation of HAc has been implicated in the pathogenesis of DN.
In this review, we focus on the recent advances on the roles of HAc and their covalent enzymes in the development and progression of DN in certain cellular processes including fibrosis, inflammation, hypertrophy, and oxidative stress and discuss how targeting these enzymes and their inhibitors can ultimately lead to the therapeutic approaches for treating DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiaoxia& Li, Chaoyuan& Sun, Guang-dong. 2016. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiaoxia…[et al.]. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiaoxia& Li, Chaoyuan& Sun, Guang-dong. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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