Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy
Joint Authors
Sun, Guang-dong
Li, Xiaoxia
Li, Chaoyuan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic nephropathy (DN) remains a leading cause of mortality worldwide despite advances in its prevention and management.
A comprehensive understanding of factors contributing to DN is required to develop more effective therapeutic options.
It is becoming more evident that histone acetylation (HAc), as one of the epigenetic mechanisms, is thought to be associated with the etiology of diabetic vascular complications such as diabetic retinopathy (DR), diabetic cardiomyopathy (DCM), and DN.
Histone acetylases (HATs) and histone deacetylases (HDACs) are the well-known regulators of reversible acetylation in the amino-terminal domains of histone and nonhistone proteins.
In DN, however, the roles of histone acetylation (HAc) and these enzymes are still controversial.
Some new evidence has revealed that HATs and HDACs inhibitors are renoprotective in cellular and animal models of DN, while, on the other hand, upregulation of HAc has been implicated in the pathogenesis of DN.
In this review, we focus on the recent advances on the roles of HAc and their covalent enzymes in the development and progression of DN in certain cellular processes including fibrosis, inflammation, hypertrophy, and oxidative stress and discuss how targeting these enzymes and their inhibitors can ultimately lead to the therapeutic approaches for treating DN.
American Psychological Association (APA)
Li, Xiaoxia& Li, Chaoyuan& Sun, Guang-dong. 2016. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
Modern Language Association (MLA)
Li, Xiaoxia…[et al.]. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
American Medical Association (AMA)
Li, Xiaoxia& Li, Chaoyuan& Sun, Guang-dong. Histone Acetylation and Its Modifiers in the Pathogenesis of Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108092