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C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy
المؤلفون المشاركون
Demir, Sevin
Temizkan, Sule
Sargin, Mehmet
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-02
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Our aim was to define the conditions that affect therapeutic success when dipeptidyl peptidase-4 (DPP-4) inhibitor is added to metformin monotherapy.
Materials and Methods.
We reviewed the medical records of 56 patients who had received DPP-4 inhibitor as an add-on to metformin monotherapy and evaluated their response in the first year of therapy.
Fasting blood glucose (FBG), HbA1c, C-peptide, and weight of the patients were recorded at 3-month intervals during the first year of treatment.
Results.
Patients who added DPP-4 inhibitor to metformin monotherapy had significant weight loss (P=0.004) and FBG and HbA1c levels were significantly lowered during the first 6 months (both P<0.001).
Baseline levels of C-peptide were predictive for success of the treatment (P=0.02), even after correction for confounding factors, for example, age, gender, or BMI (P=0.03).
Duration of diabetes was not a predictor of response to treatment (P=0.60).
Conclusion.
Our study demonstrates that in patients having inadequate glycemic control, the addition of a DPP-4 inhibitor as a second oral agent to metformin monotherapy provides better glycemic control, protects β-cell reserves, and does not cause weight gain.
These effects depend on baseline C-peptide levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Demir, Sevin& Temizkan, Sule& Sargin, Mehmet. 2016. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Demir, Sevin…[et al.]. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Demir, Sevin& Temizkan, Sule& Sargin, Mehmet. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108115
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