C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy
Joint Authors
Demir, Sevin
Temizkan, Sule
Sargin, Mehmet
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Our aim was to define the conditions that affect therapeutic success when dipeptidyl peptidase-4 (DPP-4) inhibitor is added to metformin monotherapy.
Materials and Methods.
We reviewed the medical records of 56 patients who had received DPP-4 inhibitor as an add-on to metformin monotherapy and evaluated their response in the first year of therapy.
Fasting blood glucose (FBG), HbA1c, C-peptide, and weight of the patients were recorded at 3-month intervals during the first year of treatment.
Results.
Patients who added DPP-4 inhibitor to metformin monotherapy had significant weight loss (P=0.004) and FBG and HbA1c levels were significantly lowered during the first 6 months (both P<0.001).
Baseline levels of C-peptide were predictive for success of the treatment (P=0.02), even after correction for confounding factors, for example, age, gender, or BMI (P=0.03).
Duration of diabetes was not a predictor of response to treatment (P=0.60).
Conclusion.
Our study demonstrates that in patients having inadequate glycemic control, the addition of a DPP-4 inhibitor as a second oral agent to metformin monotherapy provides better glycemic control, protects β-cell reserves, and does not cause weight gain.
These effects depend on baseline C-peptide levels.
American Psychological Association (APA)
Demir, Sevin& Temizkan, Sule& Sargin, Mehmet. 2016. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
Modern Language Association (MLA)
Demir, Sevin…[et al.]. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
American Medical Association (AMA)
Demir, Sevin& Temizkan, Sule& Sargin, Mehmet. C-Peptide Levels Predict the Effectiveness of Dipeptidyl Peptidase-4 Inhibitor Therapy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108115