The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis

المؤلفون المشاركون

Sun, Bei
Ma, Ze-jun
Zhang, Xiao-na
Wang, Ying
Li, Yu-zhu
Guo, Xin
Pan, Cong-qing
Chen, Li-Ming

المصدر

Journal of Diabetes Research

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-12-29

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments.

Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing.

In this study, we explored the effect of TLXDS on healing of diabetic wounds and investigated underlying mechanisms.

Four weeks after intravenous injection of streptozotocin, two full-thickness excisional wounds were created with a 10 mm diameter sterile biopsy punch on the back of rats.

The ethanol extract of TLXDS was given once daily by oral gavage.

Wound area, histological change, inflammation, angiogenesis, and collagen synthesis were evaluated.

TLXDS treatment significantly accelerated healing of diabetic rats and improved the healing quality.

These effects were associated with reduced neutrophil infiltration and macrophage accumulation, enhanced angiogenesis, and increased collagen deposition.

This study shows that TLXDS improves diabetes-impaired wound healing.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Xiao-na& Ma, Ze-jun& Wang, Ying& Li, Yu-zhu& Sun, Bei& Guo, Xin…[et al.]. 2015. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108161

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Xiao-na…[et al.]. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108161

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Xiao-na& Ma, Ze-jun& Wang, Ying& Li, Yu-zhu& Sun, Bei& Guo, Xin…[et al.]. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108161

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1108161