The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis
Joint Authors
Sun, Bei
Ma, Ze-jun
Zhang, Xiao-na
Wang, Ying
Li, Yu-zhu
Guo, Xin
Pan, Cong-qing
Chen, Li-Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Impaired wound healing in diabetic patients is a serious complication that often leads to amputation or even death with limited effective treatments.
Tuo-Li-Xiao-Du-San (TLXDS), a traditional Chinese medicine formula for refractory wounds, has been prescribed for nearly 400 years in China and shows good efficacy in promoting healing.
In this study, we explored the effect of TLXDS on healing of diabetic wounds and investigated underlying mechanisms.
Four weeks after intravenous injection of streptozotocin, two full-thickness excisional wounds were created with a 10 mm diameter sterile biopsy punch on the back of rats.
The ethanol extract of TLXDS was given once daily by oral gavage.
Wound area, histological change, inflammation, angiogenesis, and collagen synthesis were evaluated.
TLXDS treatment significantly accelerated healing of diabetic rats and improved the healing quality.
These effects were associated with reduced neutrophil infiltration and macrophage accumulation, enhanced angiogenesis, and increased collagen deposition.
This study shows that TLXDS improves diabetes-impaired wound healing.
American Psychological Association (APA)
Zhang, Xiao-na& Ma, Ze-jun& Wang, Ying& Li, Yu-zhu& Sun, Bei& Guo, Xin…[et al.]. 2015. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108161
Modern Language Association (MLA)
Zhang, Xiao-na…[et al.]. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108161
American Medical Association (AMA)
Zhang, Xiao-na& Ma, Ze-jun& Wang, Ying& Li, Yu-zhu& Sun, Bei& Guo, Xin…[et al.]. The Four-Herb Chinese Medicine Formula Tuo-Li-Xiao-Du-San Accelerates Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats through Reducing Inflammation and Increasing Angiogenesis. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108161