Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity
المؤلفون المشاركون
Martín-Márquez, Beatriz Teresita
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Madrigal-Ruiz, Perla Monserrat
Flores-Alvarado, Luis J.
Corona Meraz, Fernanda-Isadora
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Sandoval-Garcia, F.
Vázquez-Del Mercado, Mónica
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Obesity study in the context of scavenger receptors has been linked to atherosclerosis.
CD36 and LOX-1 are important, since they have been associated with atherogenic and metabolic disease but not fat redistribution.
The aim of our study was to determinate the association between CD36 and LOX-1 in presence of age and abdominal obesity.
Methods.
This is a cross-sectional study that included 151 healthy individuals, clinically and anthropometrically classified into two groups by age (<30 and ≥30 years old) and abdominal obesity (according to World Health Organization guidelines).
We excluded individuals with any chronic and metabolic illness, use of medication, or smoking.
Fasting blood samples were taken to perform determination of CD36 mRNA expression by real-time PCR, lipid profile and metabolic and low grade inflammation markers by routine methods, and soluble scavenger receptors (CD36 and LOX-1) by ELISA.
Results.
Individuals ≥30 years old with abdominal obesity presented high atherogenic index, lower soluble scavenger receptor levels, and subexpression of CD36 mRNA (54% less).
On the other hand, individuals <30 years old with abdominal adiposity presented higher levels in the same parameters, except LOX-1 soluble levels.
Conclusion.
In this study, individuals over 30 years of age presented low soluble scavenger receptors levels pattern and CD36 gene subexpression, which suggest the chronic metabolic dysregulation in abdominal obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Madrigal-Ruiz, Perla Monserrat& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Corona Meraz, Fernanda-Isadora& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo…[et al.]. 2016. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Madrigal-Ruiz, Perla Monserrat…[et al.]. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Madrigal-Ruiz, Perla Monserrat& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Corona Meraz, Fernanda-Isadora& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo…[et al.]. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108166
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر