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Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity
Joint Authors
Martín-Márquez, Beatriz Teresita
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Madrigal-Ruiz, Perla Monserrat
Flores-Alvarado, Luis J.
Corona Meraz, Fernanda-Isadora
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Sandoval-Garcia, F.
Vázquez-Del Mercado, Mónica
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Obesity study in the context of scavenger receptors has been linked to atherosclerosis.
CD36 and LOX-1 are important, since they have been associated with atherogenic and metabolic disease but not fat redistribution.
The aim of our study was to determinate the association between CD36 and LOX-1 in presence of age and abdominal obesity.
Methods.
This is a cross-sectional study that included 151 healthy individuals, clinically and anthropometrically classified into two groups by age (<30 and ≥30 years old) and abdominal obesity (according to World Health Organization guidelines).
We excluded individuals with any chronic and metabolic illness, use of medication, or smoking.
Fasting blood samples were taken to perform determination of CD36 mRNA expression by real-time PCR, lipid profile and metabolic and low grade inflammation markers by routine methods, and soluble scavenger receptors (CD36 and LOX-1) by ELISA.
Results.
Individuals ≥30 years old with abdominal obesity presented high atherogenic index, lower soluble scavenger receptor levels, and subexpression of CD36 mRNA (54% less).
On the other hand, individuals <30 years old with abdominal adiposity presented higher levels in the same parameters, except LOX-1 soluble levels.
Conclusion.
In this study, individuals over 30 years of age presented low soluble scavenger receptors levels pattern and CD36 gene subexpression, which suggest the chronic metabolic dysregulation in abdominal obesity.
American Psychological Association (APA)
Madrigal-Ruiz, Perla Monserrat& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Corona Meraz, Fernanda-Isadora& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo…[et al.]. 2016. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
Modern Language Association (MLA)
Madrigal-Ruiz, Perla Monserrat…[et al.]. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
American Medical Association (AMA)
Madrigal-Ruiz, Perla Monserrat& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Corona Meraz, Fernanda-Isadora& Vázquez-Del Mercado, Mónica& Gómez-Bañuelos, Eduardo…[et al.]. Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108166