The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio
المؤلفون المشاركون
Lv, Chuan
Wang, Qiuyue
Lu, Canlu
Wu, Can
Ma, Xiao-yu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.
Methods.
464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n=157), microalbuminuria group (MA, n=159), and large amount of albuminuria group (LA, n=148).
127 healthy persons were selected as the control group (NC, n=127).
The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay.
The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.
Results.
The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P<0.01).
The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P<0.01).
The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P<0.01).
Conclusions.
These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xiao-yu& Lu, Canlu& Lv, Chuan& Wu, Can& Wang, Qiuyue. 2016. The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108214
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xiao-yu…[et al.]. The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio. Journal of Diabetes Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108214
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xiao-yu& Lu, Canlu& Lv, Chuan& Wu, Can& Wang, Qiuyue. The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108214
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108214
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر