The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio

Abstract EN

Objective.

To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.

Methods.

464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA, n=157), microalbuminuria group (MA, n=159), and large amount of albuminuria group (LA, n=148).

127 healthy persons were selected as the control group (NC, n=127).

The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-β1 (TGF-β1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay.

The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.

Results.

The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (P<0.01).

The TGF-β1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (P<0.01).

The expression of miR-192 was negatively correlated with TGF-β1, FN, and Ln (UACR) and miR-192, TGF-β1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (P<0.01).

Conclusions.

These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.